Stress sensitivity exists in oil-gas reservoir. There is a lot of report about stress sensitivity in porous and fractured reservoirs while less attention is paid to stress sensitivity in the fractured-vuggy reservoir. The fractured-Vuggy carbonate reservoir of Tahe oilfield as a case was subjected to simulate stress sensitivity experiment by choosing natural fractured, artificial fractured, single-cavity and double-cavity core samples. Experimental results from 12 rock samples of 4 groups show that stress-sensitive coefficients of the natural fractured, artificial fractured, single cavity, and double cavity core are 0.64, 0.75, 0.58  and 0.61 respectively, corresponding to the stress-sensitive degree changed from med\|strong,strong,med-strong, and med-strong, respectively. After 60h of samples download, the final return permeability rate of rock samples is 69.84%, 4.36%, 11.86% and 38.75%, respectively. Thus, the existence of cavity would weak the stress\|sensitive degree of fractured reservoir, and the development of cavity also increases the hardness of controlling drill-in fluid loss damage.