The nose structure is an important location for hydrocarbon accumulation. Based on the analysis of its geological background and oil geological factors, the basic features of Cenozoic hydrocarbon accumulation in the Honggouzi structure is discussed. Firstly, the structure undergoes depression, extrusion and finalization in the front of the Altun Mountain since the Cenozoic, and abundant source reservoir seal assemblages which has good space-time association are formed. Secondly, the structure develops two types of oil-gas reservoirs: crack-pore type which is distributed in the east of the structure, and pore type which is distributed in the superficial layer of west structure.