In the developing of deformed media gas reservoir, the stress of reservoir rock will be changed by outflow of the gas, and the rock will have elastoplastic deformation, on the contrary, the deformation influence permeability of reservoir. Commonly, the influence factors include interior factors and exterior factors: the interior factors include elasticity module, Poisson ratio and moisture saturation, and the exterior factors include the cover terrane pressure, level stress and fluid pressure. The influences for permeability of reservoir is effectively by analyze the factors. In order to develope these reservoirs, these factors must be considered. And the study for the factors will offer a theory for reasonably developing of deformed media gas reservoirs.