By the three facies integrated interpretation technique, which is the combination of log facies, seismic facies and sedimentary microfacies, the favorable sequences in vertical and the favorable regions in plane are determined to explore the lithologic reservoirs of the Shengbei region in the Turpan-harmy basin. Log facies combined with the core observation is to define the sedimentary microfacies type of the main exploration formation in the well points. Seismic facies analysis is to define the seismic facies variation of the main exploration formation in plane. Sedimentary microfacies is to define the microfacies variation as a whole according to the microfacies combination pattern established by single well etc. The "three facies" integrated interpretation result may be directly used to select the favorable sequences in vertical and the favorable region in plane to explore lithologic reservoirs. The method is applied in the Shengbei region of the Turpan-harmy basin. The middle fan braided channels of alluvial fans of the Kalazha Formation in the Shengbei structural belt and its south flank are determined as the favorable positions for exploration. The selected and employed target of Well Shengbei 16 gets a good exploration result. The application shows that this technique is an effective way for the lithologic reservoir exploration in regions with good quality of seismic data, simple structures and certain degree of exploration.