Based on summering predecessors work, this paper analyses the destroy mechanism of oil and gas reservoirs and their actual examples through the four aspect of uplift and denudation of crust, activity of faults, movement of underground water and gas diffusion. Considers uplift and denudation of crust and activity faults to be the basically cause that oil and gas reservoirs had been distracted uplift of crust and opened faults that can fault to the surface can’t destroy oil and gas reservoirs, but is can cause the secondary distribution of oil and gas. Reduce the scale of original oil and gas reservoirs. The destroy of movement of underground water to oil and gas reservoirs is decided by upiilt and denudation of crust and activity of faults. It can directly destroy oil and gas reservoirs by washing- It can also destroy oil and gas reservoirs by promoting oxidation and bacteria degradation. Gas diffusion makes reserves of gas reservoirs decrease and exhaustion.