The south-west Qaidam basin is the high exploration degree region and has the large resource potential, so it become the favorable area for sandbody lithological reservoirs exploration. Along with exploration increase, the key problems of confinement exploration become gradual exposal. We have studied the accumulation model of petroleum and sedimentary facies, and interpreted the 3-D seismics. The result of study show that ramp grade of Gasi is the favorable area for seeking sandbody lithological reservoirs on E+1-3, we should seek the sandbody lithological reservoirs along the nose hump on ramp grade. At the same time, Yuexi structure slope belt is the favorable area for seeking sandbody lithological reservoirs, the major problem is finding algal limestone and defining the distributing dimension. Buial hill zone is important field for exploration in Yuexi region. There is the nose hump at the south of Yueshen11 drill on the ramp grade of Yuejinerhao, it's tectonic setting and conditions of formation are similar with that of Yuejinsihao region, so it is still important field for sandbody lithological reservoirs exploration.