On the basis of the review of present exploration situation and prospecting of litho-stratigraphic reservoirs in main oil-gas bearing basins of China continent. The author systemically concluded the recent advances of the exploration techniques of litho-stratigraphic reservoirs. The result shows that on the basis of microfacies analysis and stratigraphic sequence study, the synthetic evaluation of seismic multi-parameters is an effective approach in litho-stratigraphic reservoir exploration. In this method, the key techniques are as following: microfacies, high-resolution stratigraphic sequence, seismic facies, general and unusual reservoir prediction, seismic attributes, fluid trend analysis, oil-gas detection and 3D visualization etc.